In March 1918 an army cook reported to the infirmary at Fort Riley, Kansas, with a temperature of 39.5 C.
Within two days a further 521 men had been taken sick, in what is thought to have been one of the first recorded outbreaks of what came to be known as Spanish flu.
Striking a world already devastated by war, such early warning signs were largely missed and the influenza went on to kill 40 million in a matter of months.
Scientists now believe the virus came from birds and that it bore similarities to the avian flu at the centre of the current scare.
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News Health Avian flu Bird flu H5N1 Pandemic Influenza Spanish Flu Kansas Flu